What's your
Stem cell vision?
Repair A
Damaged
Heart
What's your
Stem cell vision?
Restore
eyesight
What's your
Stem cell vision?
Treat
Parkinson's

High Quality and Yield

To develop a therapy for heart failure, to treat Parkinson’s or to restore damaged eyesight? Whatever your stem cell vision is, you need a culture substrate that guarantees the highest cell quality and yield.

Human embryogenesis and the body’s ability to repair itself is remarkable – Let’s use the knowledge we have generated to develop effective stem cell therapies - to help the body help itself. To help the body to help itself. An important key to success is a culture substrate that guarantees the highest cell quality and yield.

Culturing cells is about growing human cells outside the human body. To develop a differentiation protocol that generates the target cell type at a sufficient quantity and purity and with high phenotypic maturity is arguably challenging. Following this, the advancement from pre-clinical studies to a Phase 1 clinical trial requires a well-controlled production process and a safe and efficacious cell product. In order to successfully transition from basic cell therapy research to the clinic, researchers have to be innovative and ready to push the frontiers of research.

While many protocols successfully recapitulate the temporal developmental processes via well designed medium formulations, the majority of protocols ignore the role of basement membrane proteins. The concept of adhesive matrix molecules is gradually growing, where adhesion is not only about making cells stick, but also about the interaction between the culture substrate and cells which can influence cell behavior. The type of cell culture substrate used will have a great impact on your research and will save you both time and cost. Yet 40% of scientists use undefined cell culture substrates where more than 60% are facing issues such as low cell yield and bad cell quality, and are struggling with laborious, inconsistent and operator-dependent procedures. Moreover, almost 90% of these scientist state that they have issues maintaining a homogenous stem cell population, having to spend time on manually removing differentiated cell areas. Take our Stem Cell Research Protocol Survey to get a better understanding of some of the issues involved in generating robust protocols for isolation, expansion and differentiation of human stem cells.

The quality and biological relevance of your substrate is of even more importance if you have a cell therapy focus. It is also here, when moving into clinical trials, that most scientists run into problems related to their substrates. Given its importance, it is surprising to see how many stem cell scientists do not prioritize substrate quality and do not choose a culture substrate that is best suited for their specific cell type and research focus. Are you using the right matrix for your cells?

More information

Read more about the importance of stem cell substrates

Body’s natural substrates

When growing stem cells outside the body, what could be more natural than mimicking the cell environment in the human body?

Researchers who work with adherent cells need a culture substrate. Most organized and stationary cells of the body grow on specialized basement membranes and different cells and tissues require their specific protein composition for survival and proper function. So, when growing stem cells outside the body, wouldn’t it be natural to mimic the cell environment in the human body?

Laminins are key components of the basement membrane which adhere to the cells, maintain the subcultural organization of the basement membrane and play an essential role in the regulation of cell behaviour. This makes laminins the optimal cell culture substrate, nature’s own, with the highest biological relevance, by definition. Via their interaction with specific cellular receptors, laminins trigger authentic cell signalling pathways, promoting high survival, organization and keeping the cells functional, ultimately allowing scientists to generate superior research results. Read more!

Supporting Articles

Read more about using laminin as a stem cell substrate

Biolaminin – from idea to therapy

A complete portfolio of substrates from BioLamina, based on full-length, recombinant laminin 521.

With our new cell therapy grade product, Biolaminin 521 CTG, BioLamina can support scientists throughout their cell therapy development process – from concept to commercialized therapy. Scientists who are at an early research stage will enjoy a seamless transition from basic research to post-approval therapy and production – using Biolaminin 521 research grade products (LN or MX) followed by Biolaminin 521 CTG. For your discovery and pre-clinical development phases, we recommend using Biolaminin 521 MX, and then upgrading to Biolaminin 521 CTG once you enter your clinical development phase.

Scientifically validated laminin products

BioLamina's Biolaminin 521 products are all full-length, human, recombinant laminin 521 substrates, the only ones on the market.

Biolaminin 521 CTG is the world’s first cell therapy grade laminin product. This new product complements BioLamina’s renowned research grade laminin product, Biolaminin 521 LN -  the original product (LN521). As a complement to the CTG product, Biolaminin 521 MX has been developed to facilitate the conversion from the research grade laminin (LN) substrate to the CTG substrate, facilitating a seamless transition from discovery to clinical settings. There are only a few cell therapy grade compliant stem cell matrices currently on the market, none of which are as biologically relevant as BioLamina’s. The impact of the laminin matrices on cell-culture quality has been scientifically validated in many high-impact journals.

Biologically relevant

The biologically relevant support improves cell performance and decreases variance.

High expansion rate

Fast proliferation rate with maintained genetic integrity facilitates the use of low passage cell lines for the production of clinically relevant cell numbers of differentiated cell types.

Minimized variation

No lot-to-lot variation and uniformed pluripotency gene expression patterns gives more standardized experiments.

Effective specialization

More efficient differentiation, enhanced cell maturation, polarization and organization of specialized cell types, such as hepatocytes, cardiomyocytes and neurons.

Defined and xeno-free

The products are defined and animal-origin free. All materials used in the production of Biolaminin 521 CTG have full traceability.

Full documentation

Full traceability documentation, such as Certificate of Origin and Certificate of Analysis are available for the cell therapy grade Biolaminin 521.

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CONTACT information

Technical support

Email: technical@biolamina.com
Tel: +46-8-5888 51 80

Sales support

Email: sales@biolamina.com
Tel: +46-8-5888 51 80

Meet us here

Our dedicated team of experts are present at most of the important tradeshows around the world. You are welcome to discuss your stem cell vision with us!

12-14 November in Ottawa, Canada

The 2018 Till & McCulloch Meetings

Go to the conference website here!

28-30 November in Lisbon, Portugal

World Preclinical Congress

Go to the conference website here!

videos and webinars

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On demand webinar

Biolaminin 521 CTG - a cell culture substrate designed for clinical research

Dr. Therese Kallur, Business Development Manager, BioLamina

Watch video on YouTube

CUSTOMER SUSSESS STORIES

Stem cell-based treatment for Parkinson's disease

Prof. Malin Parmar, Lund University, Sweden

Watch video on YouTube

CUSTOMER SUSSESS STORIES

Generation of clinically compliant hESC/RPE cells for treatment of macular degeneration

Assoc. Prof. Fredrik Lanner, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden

Watch video on YouTube

Testimonials

"The use of recombinant laminins in conjunction with our differentiation systems have significantly advanced stem cell derived hepatocyte performance and polarity. Importantly, those processes are now fully defined, and GMP ready, offering exciting prospect for human regenerative medicine”

Dr. David Hay, MRC Centre for regenarative medicine, University of Edinburgh, UK

"We have struggled for a number of years to establish a GMP manufacturing process for  generating DA neurons from human embryonic stem cells in order to develop a stem cell  based therapy for Parkinson’s Disease. The recombinant laminins from Biolamina really  made a world of difference! We now routinely use LN521 and EDTA for passaging the  pluripotent stem cells and we have a greater efficiency than ever before. It also turns out  that the DA progenitor cells love to grow on LN111 and after introducing this into our  protocol we now have a high yield, high quality GMP differentiation ready to use”

Prof. Malin Parmar, Lund University, Sweden

"By introducing the use of Biolaminin 521, shifting our culture methods away from relying on murine embryonic fibroblasts (MEF) or other less defined substrates, we have simplified the day-to-day expansion of our human pluripotent stem cells and significantly reduced the amount of required operator time. I am pleased to find that our new costs are only a fraction (7%) of what they used to be when we relied on traditional methods that used MEF."

Dr. Roger E. Rönn, University of Edinburgh, UK.

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